Striking Scientific Images
Image shows mitochondria in heart cells after the levels of tristetraprolin (TTP) — the master regulator of cellular iron conservation — are reduced. Northwestern Medicine scientists shows that TTP is activated during iron deficiency and lowers iron usage to match availability and prevents mitochondrial dysfunction. (Research published in Proceedings of the National Academy of Sciences)
Centromeric nucleosomes, containing CENP-A (red) must be retained in the preceding S-phase for the centromere to correctly assemble and segregate chromosomes during mitosis. Loss of centromere function leads to chromosome instability, which is a common characteristic of cancer cells. (Research published in Developmental Cell)
Fasting for 24 hours induced dramatic formation of autophagic vesicles (green dots, labeled by a marker protein LC3 tagged with the green fluorescent protein) in skeletal muscle. Blue indicates stained nuclei. (Research published in Nature)
A dense gap-junction network formed between nNOS-2 amacrine cells, the main source of the neuromodulator nitric oxide in the mouse retina. Here, a single nNOS-2 amacrine cell was patched and filled with dye to reveal this network when imaged with a multiphoton laser. The large molecule fluorescent dye Alexa Fluor 488 readily passes through nNOS-2 amacrine cell gap junctions when they are in the most open state in dark conditions. (Research published in Neuron)
SCIENTIFIC IMAGES COURTESY OF Hossein Ardehali, MD, PhD (upper left), Daniel Foltz, PhD (upper right), CongCong He, PhD (lower left), and Jason Jacoby, PhD (lower right).