Eating Eggs and Cholesterol Linked to Heart Disease and Death Risk

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Cancel the cheese omelet. There is sobering news for egg lovers who have been happily gobbling up their favorite breakfast since the 2015-2020 Dietary Guidelines for Americans no longer limited how much dietary cholesterol or how many eggs they could eat.

A large new Northwestern Medicine study published in JAMA reports adults who ate more eggs and dietary cholesterol had a significantly higher risk of cardiovascular disease and death from any cause.

“The take-home message is really about cholesterol, which happens to be high in eggs and specifically yolks,” said co-corresponding study author Norrina Allen, PhD, associate professor of Preventive Medicinein the division of Epidemiology. “As part of a healthy diet, people need to consume lower amounts of cholesterol. People who consume less cholesterol have a lower risk of heart disease.”

Other animal products such as red meat, processed meat and high-fat dairy products (butter or whipped cream) also have high cholesterol content, said lead author Wenze Zhong, PhD, a postdoctoral fellow in preventive medicine at Northwestern.

The JAMA study reports adults who ate more eggs and dietary cholesterol had a significantly higher risk of cardiovascular disease and death from any cause.

The great debate

Whether eating dietary cholesterol or eggs is linked to cardiovascular disease and death has been debated for decades. Eating less than 300 milligrams of dietary cholesterol per day was the guideline recommendation before 2015. However, the most recent dietary guidelines omitted a daily limit for dietary cholesterol. The guidelines also include weekly egg consumption as part of a healthy diet.

An adult in the U.S. gets an average of 300 milligrams per day of cholesterol and eats about three or four eggs per week.

The study findings mean the current U.S. dietary guideline recommendations for dietary cholesterol and eggs may need to be re-evaluated, the authors said.

The evidence for eggs has been mixed.  Previous studies found eating eggs did not raise the risk of cardiovascular disease. But those studies generally had a less diverse sample, shorter follow-up time and limited ability to adjust for other parts of the diet, Allen said.

“Our study showed if two people had exact same diet and the only difference in diet was eggs, then you could directly measure the effect of the egg consumption on heart disease,” Allen said. “We found cholesterol, regardless of the source, was associated with an increased risk of heart disease.”

Exercise, overall diet quality and the amount and type of fat in the diet didn’t change the association between the dietary cholesterol and cardiovascular disease and death risk.

The new study looked at pooled data on 29,615 U.S. racially and ethnically diverse adults from six prospective cohort studies for up to 31 years of follow up and found:
  • Eating 300 mg of dietary cholesterol per day was associated with 17 percent higher risk of incident cardiovascular disease and 18 percent higher risk of all-cause deaths. The cholesterol was the driving factor independent of saturated fat consumption and other dietary fat.
  • Eating three to four eggs per week was associated with 6 percent higher risk of cardiovascular disease and 8 percent higher risk of any cause of death.

 

Should I stop eating eggs? 

Based on the study, people should keep dietary cholesterol intake low by reducing cholesterol-rich foods such as eggs and red meat in their diet, but they shouldn’t completely banish eggs and other cholesterol-rich foods from meals, Zhong said. Eggs and red meat are good sources of important nutrients such as essential amino acids, iron and choline. Instead, choose egg whites over whole eggs or eat whole eggs in moderation, he said.

“We want to remind people there is cholesterol in eggs, specifically yolks, and this has a harmful effect,” said Allen, who cooked scrambled eggs for her children that morning. “Eat them in moderation.”

How the study was conducted

Diet data were collected using food frequency questionnaires or by taking a diet history. Each participant was asked a long list of what they’d eaten for the previous year or month. The data were collected during a single visit. The study had up to 31 years of follow up (median: 17.5 years), during which 5,400 cardiovascular events and 6,132 all-cause deaths were diagnosed.

A major limitation of the study is participants’ long-term eating patterns weren’t assessed.

“We have one snapshot of what their eating pattern looked like,” Allen said. “But we think they represent an estimate of a person’s dietary intake. Still, people may have changed their diet, and we can’t account for that.”

Other Northwestern authors include: Linda Van Horn, PhD, associate dean for Faculty Development and chief of Nutrition in the Department of Preventive Medicine; Marilyn Cornelis, PhD, assistant professor of Preventive Medicine in the division of Nutrition; John Wilkins, MD, assistant professor of Medicine  in the Division of Cardiology and of Preventive Medicine; Hongyan Ning, MD, MS; Mercedes Carnethon, PhD, vice chair and Chief of Epidemiology in the Department of Preventive Medicine; Philip Greenland, MD, the Harry W. Dingman Professor of Cardiology and of Preventive Medicine in the Division of Epidemiology; Lihui Zhao, PhD, associate professor of Preventive Medicine in the Division of Biostatistics and Donald Lloyd-Jones, MD, ScM, Senior Associate Dean for Clinical and Translational Research and chair of the Department of Preventive Medicine.

The study was supported in part by the American Heart Association and by the National Heart,Lung and Blood Institute grants R21 HL085375, HHSN268201300046C, HHSN268201300047C, HHSN268201300049C, HHSN268201300050C, HHSN268201300048C of the National Institutes of Health.